International Myeloma Working Group molecular classification of multiple myeloma: spotlight review
نویسندگان
چکیده
منابع مشابه
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
PURPOSE The clinical outcome of multiple myeloma (MM) is heterogeneous. A simple and reliable tool is needed to stratify patients with MM. We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in n...
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The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities such as t(4;14), del(17/17p), t(14;16), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis. The prognosis of patients showing these abnormalities may vary with the choice of therapy. Treatment strate...
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This International Myeloma Working Group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions). These changes are based on the identification of biomarkers associated with near inevitable development of CRAB features in patients who...
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MA Hussein, FD Vrionis, R Allison, J Berenson, S Berven, E Erdem, S Giralt, S Jagannath, RA Kyle, S LeGrand, R Pflugmacher, N Raje, SV Rajkumar, L Randall, D Roodman, D Siegel, R Vescio, J Zonder and BGM Durie on behalf of the International Myeloma Working Group Department of Hematologic Malignancies, H Lee Moffitt Cancer Center, Tampa, FL, USA; Department of Neuro-Oncology, H Lee Moffitt Cance...
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The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigati...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2009
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2009.174